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Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma

โœ Scribed by Snijders, Antoine M; Schmidt, Brian L; Fridlyand, Jane; Dekker, Nusi; Pinkel, Daniel; Jordan, Richard C K; Albertson, Donna G


Book ID
110069652
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
454 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract Cyclin E and Cdk2 have been shown to play an important role in G1/S transition of the cell cycle. Two Eโ€type cyclins (E1 and E2) have been identified to date and share functionally similarities. Upregulation of these cyclins has been observed frequently in human cancers. We examined the