Rapidly recurrent enteroviral meningitis in non-immunocompromised infants caused by different viral strains
✍ Scribed by Nectar Aintablian; R. Douglas Pratt; Mark H. Sawyer
- Book ID
- 102379309
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 429 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0146-6615
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Repeated episodes for enteroviral meningitis occurring within a 1‐month priod in two non‐immunocompromised infant were investigated using molecular techniques to distinguish persistent or recrudescent infection from new infection. Viral RNA from cerebrospinal fluid was amplified by polymerase chanin reaction, cloned, and the nucleic acid sequences determined. This analysis demonstrated that both infants had recurrent episodes of meningitis caused by new infection with a distincy enterovirus strain. The moleular methods that were employed should prove useful in similar clinical settings as well as for the study of enteroviral outbreaks. These cases also illustrate the potential for rapid reinfection of infants with different viruses of the same genus. © 1995 WiIey‐Liss, Inc.