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Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity

✍ Scribed by Nejib Mourali; Paul H. Levine; Francoise Tabanne; Slim Belhassen; Jacqueline Bahi; Meri Bennaceur; Ronald B. Herberman

Publisher: John Wiley and Sons
Year: 1978
Tongue: French
Weight: 317 KB
Volume: 22
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910220102

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✦ Synopsis

Abstract

Delayed hypersensitivity reactions to a battery of antigens were measured in 145 Tunisian breast cancer patients to determine whether an immuno‐logic mechanism could be detected which might explain the high frequency (60%) of the rapidly progressing form in Tunisian breast cancer patients. Although a greater proportion (30%) of patients with rapidly progressing breast cancer reacted to extracts of a breast tumor antigen (2937) than patients without PEV (9%), no significant difference between PEV and non‐PEV patients could be found in reactivity to DNCB, standard microbial antigens, or extracts from tissue culture cell lines. Rapidly progressing breast cancer in Tunisia is not associated with an impairment of delayed hypersensitivity.

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## Abstract It has been suggested that poussée évolutive (PEV) or rapidly progressing breast cancer (RPBC) represents a failure in the host immune system to control the proliferation of breast cancer cells. To evaluate this possibility, we have performed __in vivo__ and __in vitro__ assays of cellu