Annualized rates of cognitive change in Alzheimer's disease (AD), an important index of disease progression, show marked variability. To determine factors leading to such variability, we computed rates of change in a cohort of patients with AD tested annually with the Mini Mental State Examination (
Rapidly evolving EEG changes in a case of alzheimer disease
β Scribed by Dr. Albert L. Ehle; Peter C. Johnson
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 306 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
A patient who presented with a subacutely evolving dementia and electroencephalographic changes resembling those reported in CreutzfeldtβJakob disease was found at autopsy to have Alzheimer disease. Despite typical clinical and electroencephalographic findings, accurate discrimination between these two diseases depends on pathological examination.
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Dementia is characterized by accelerated cognitive decline before and after diagnosis as compared to normal ageing. Determining the time at which that rate of decline begins to accelerate in persons who will develop dementia is important both in describing the natural history of the disease process
## Abstract Alzheimer's disease (AD) is characterized by an extensive loss of cholinergic neurons, and their cortical projections, from the basal forebrain area. The resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ACh), decrease