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Rapid Target Analysis by On-line Single Short-column Liquid Chromatography/Thermospray Tandem Mass Spectrometry

✍ Scribed by W. A. Minnaard; A. C. Hogenboom; U. K. Malmqvist; P. Manini; W. M. A. Niessen; U. A. Th. Brinkman

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 559 KB
Volume: 10
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(199610)10:13<1569::aid-rcm650>3.0.co;2-p

No coin nor oath required. For personal study only.

✦ Synopsis

The feasibility of on-line sample pretreatment and separation on a single short-column liquid chromatography/ tandem mass spectrometry (LC/MS/MS) system is tested for target analysis of triazines in surface water. In this approach, the chromatographic separation is reduced to a minimum, primarily aiming at resolving the peaks of interest from the solvent front and other disturbing interferences. Preliminary experiments with a thermospray interface allowed the detection of triazines down to the 1 cI.g/L level by analyzipg 48 mL of spiked surface water. Good linearity in the range of l-lOpg/L and relative standard deviations better than 8% indicate the practicability of the single short-column LC/MS/MS approach.

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