Rapid screening of the entire mitochondrial DNA for low-level heteroplasmic mutations
β Scribed by David Meierhofer; Johannes A. Mayr; Sabine Ebner; Wolfgang Sperl; Barbara Kofler
- Book ID
- 116751473
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 418 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1567-7249
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Molecular analysis of mitochondrial DNA (mtDNA) is a critical step in diagnosis and genetic counseling of respiratory chain defects. No fast method is currently available for the identification of unknown mtDNA point mutations. We have developed a new strategy based on complete mtDNA PCR amplificati
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