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Rapid Screening of Drug Absorption Potential Using the Immobilized Artificial Membrane Phosphatidylcholine Column and Molar Volume

✍ Scribed by C. H. Yoon; B. S. Shin; H. S. Chang; L. S. Kwon; H. Y. Kim; S. E. Yoo; S. D. Yoo


Book ID
111788206
Publisher
Springer
Year
2004
Tongue
English
Weight
400 KB
Volume
60
Category
Article
ISSN
0009-5893

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## Abstract This study reports a rapid screening method for the prediction of oral drug bioavailability in humans based on combined immobilized artificial membrane (IAM) chromatographic capacity factor (__k__~IAM~) and __in vitro__ stability in hepatic microsomes. The fraction of drug absorbed (__F