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Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity

✍ Scribed by L. Kostenko; L. Kjer-Nielsen; I. Nicholson; F. Hudson; A. Lucas; B. Foley; K. Chen; K. Lynch; J. Nguyen; A. H. B. Wu; B. D. Tait; R. Holdsworth; S. Mallal; J. Rossjohn; M. Bharadwaj; J. McCluskey


Book ID
110893354
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
814 KB
Volume
78
Category
Article
ISSN
0001-2815

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ABC) is an antiretroviral drug highly effective in the treatment of HIV, but its intake can cause severe hypersensitivity reaction (HSR). A strong association between HLA-B Γƒ 57:01 and ABC HSRs was reported by several studies, which demonstrated that HLA-B Γƒ 57:01 screening had a 100% negative predi