Rapid reversal of no-reflow using abciximab after coronary device intervention

✍ Scribed by Rawitscher, David ;Levin, Thomas N. ;Cohen, Ian ;Feldman, Ted

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 94 KB
• Volume: 42
• Category: Article
• ISSN: 0098-6569
• DOI: 10.1002/(sici)1097-0304(199710)42:2<187::aid-ccd20>3.0.co;2-k

✦ Synopsis

The no-reflow phenomenon is a reduction in epicardial coronary artery blood flow without mechanical vessel obstruction. Early descriptions of this syndrome involved reperfusion after myocardial infarction. More recently, the no-reflow phenomenon has been recognized after brief ischemic times associated with coronary interventions. It is clearly a negative prognostic indicator. The proposed mechanism is multi-factorial and may involve small vessel vasospasm and potentially platelet-mediated loss of capillary autoregulation. Because of the potential role of platelets in the genesis of the no-reflow state, we administered Abciximab to two patients with no-reflow phenomenon following catheter interventions. In both of these settings, rapid distal runoff was reestablished within minutes after treatment with the platelet glycoprotein 2B/3A inhibitor.