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Rapid resolution liquid chromatography–mass spectrometry determination of SAR97276 in monkey matrices. Pharmacokinetics in rhesus monkey infected by Plasmodium cynomolgi

✍ Scribed by D. Margout; N. Bontemps; C.H.M. Kocken; H.J. Vial; F.M.M. Bressolle


Book ID
111713319
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
295 KB
Volume
49
Category
Article
ISSN
0731-7085

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## Abstract 1,12‐Bis[5‐(2‐hydroxyethyl)‐4‐methyl‐1,3‐thiazol‐3‐ium]dodecane dibromide (SAR97276, T3) is a new antimalarial drug, which is currently being evaluated in clinical trials for severe malaria. Drug accumulation inside the parasite and a dual mechanism of action are a major strength of thi