Anticipation has been suggested among the genetic mechanisms of bipolar disorder (BD), prompting the search for unstable DNA sequences. Past studies of anticipation in BD have generally relied on observed shift in the age at onset between parental and offspring generations. Such a shift, however, ma
Rapid onset: A valid panic disorder criterion?
โ Scribed by Barbara S. Scupi; Brenda E. Benson; Lauren B. Brown; Thomas W. Uhde
- Book ID
- 101295023
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 75 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1091-4269
No coin nor oath required. For personal study only.
โฆ Synopsis
This study examined the value of the DSM-IV time criterion for panic disorder (PD) requiring an abrupt onset to panic attacks (PAs) with a time to peak intensity (TTPI) of less than 10 min, and evaluated features distinguishing rapid onset (TTPI < 10) from prolonged onset (TTPI > 10) panickers. Eight hundred and sixty-four respondents to the National Institute of Mental Health Panic Disorder Questionnaire (NIMH PQ) who met the first three PD criteria were compared based on the time criterion. The prolonged onset panickers (18.2%) did not differ significantly from rapid onset panickers (81.8%) on any of 100 items assessing clinical symptoms, course of illness, and comorbidity of PD. These results suggest that many patients with otherwise classic features of PD have a prolonged TTPI of PAs, and that patients with prolonged-onset PAs are similar to patients with rapid-onset PAs on most measures. The reliability, validity, and clinical relevance of the current DSM-
IV TTPI criterion should be evaluated in future studies. Depression and Anxiety 5:121-126, 1997.
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A case of late-onset bipolar rapid cycling affective disorder of classical cycle length is presented. The aetiology and management of the disorder is discussed. The case adds to other evidence that the symptoms of affective disorder in old age are similar to those in younger patients. KEY woms-Rapi
## Abstract Recently, testing for anticipation has received renewed interest. It is well known that standard statistical methods are inappropriate for this purpose due to problems of sampling bias. Few statistical tests have been proposed for comparing mean age of onset in affected parents with mea