The purpose of this study was to determine the proportion of fetal nucleated red blood cells (NRBCs) among enriched NRBCs and to evaluate the effectiveness of enriching NRBCs in maternal blood using fluorescenceactivated cell sorting (FACS) to separate NRBCs. The origin of enriched NRBCs was determi
Rapid On-Slide Location and Analysis of Enriched Fetal Nucleated Cells from Maternal Blood
โ Scribed by M. GAUDOIN; D. RUTOVITZ; J. PIPER; P. EASON; H. FINLAYSON; A. E. HILL; J. FANTES; P. PERRY; I. POOLE; J. B. SCRIMGEOUR; V. VAN HEYNINGEN
- Book ID
- 119871277
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 73 KB
- Volume
- 731
- Category
- Article
- ISSN
- 0890-6564
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Chorionic villus sampling (CVS) is an established invasive prenatal diagnostic method for the detection of fetal chromosome aberrations. In 1-2% the karyotype result of CVS is inconclusive and follow-up confirmation will be required. To avoid another invasive procedure we examined fetal nucleated re
In this study we evaluated the performance of a system for the enrichment, identification and analysis of fetal cells in maternal peripheral blood. Blood samples were collected from women after chorionic villus sampling and enriched for the presence of nucleated erythrocytes using a three-step proc