𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Rapid MR imaging of a vascular challenge to focal ischemia in cat brain

✍ Scribed by Alexander J. De Crespigny; Michael F. Wendland; Nikita Derugin; Zinaida S. Vexler; Michael E. Moseley

Book ID
102905236
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
773 KB
Volume
3
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Deoxygenated blood was effectively used as a magnetic resonance (MR) susceptibility contrast agent to distinguish perfused and nonperfused (ischemic) regions in a focal ischemia model in cat brain at 2 T. Modulation of cerebral blood oxygenation levels in response to apnea was followed in real time with T2*‐weighted (gradient‐recalled) echo‐planar MR imaging. Signal loss in the T2*‐weighted images occurred only in perfused tissues as blood became globally deoxygenated. These data complemented information from diffusion‐weighted and contrast agent bolus–‐tracking images. In addition, observation of the signal recovery behavior on reventilation in both normal and ischemic brain offered potentially useful information about the state of the cerebral autoregulatory mechanism.

📜 SIMILAR VOLUMES

Real-time observation of transient focal
Real-time observation of transient focal ischemia and hyperemia in cat brain
✍ A. J. De Crespigny; M. F. Wendland; N. Derugin; E. Kozniewska; M. E. Moseley 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB

## Abstract Gradient‐recalled echo‐planar (T2‐weighted) imaging was used to noninvasively monitor regional blood oxygenation state changes in real time during transient episodes of focal ischemia in cat brain. Varying ischemic intervals (12 s to 30 min) were caused by middle cerebral artery occlusi

Changes in metabolites and tissue water
Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy
✍ Annette van der Toorn; Hieronymus B. Verheul; Jan-Willem Berkelbach van der Spre 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 698 KB

## Abstract Localized proton spectroscopy was used to monitor changes in metabolism and the biophysical status of tissue water in cat brain induced by occlusion of the middle cerebral artery. Changes in the intensity of __N__‐acetyl‐aspartate (NAA), total creatine (tCr), and lactate (Lac) signals i

Quantitation and localization of blood-t
Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemia
✍ Robert A. Knight; Tavarekere N. Nagaraja; James R. Ewing; Vijaya Nagesh; Polly A 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 840 KB

## Abstract The ability of gadolinium‐diethylenetriaminepentaacetic acid (Gd‐DTPA) enhanced MRI to localize and quantitate blood–brain barrier (BBB) opening was evaluated against quantitative autoradiographic (QAR) imaging of ^14^C‐α‐aminoisobutyric acid (AIB) distribution. The blood‐to‐brain trans