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Rapid Microwave-Assisted Liquid-Phase Combinatorial Synthesis of 2-(Arylamino)benzimidazoles

โœ Scribed by Bendale, Pravin M.; Sun, Chung-Ming


Book ID
125896177
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
77 KB
Volume
4
Category
Article
ISSN
1520-4766

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โœ Chih-Ming Yeh; Chung-Ming Sun ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 244 KB

An efficient liquid-phase synthesis of 2-alkylthio-5-carbamoylbenzimidazoles 1 is described. Immobilized ofluoronitrobenzene 2 undergoes nucleophilic addition of primary amine to afford o-nitroaniline derivatives 3. Subsequent reduction of the aromatic nitro group followed by cyclization gives a PEG