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Rapid kinetics of tyrosyl radical formation and heme redox state changes in prostaglandin H synthase-1 and -2

✍ Scribed by Ah-Lim Tsai; Gang Wu; Graham Palmer; Bijan Bambai; James A. Koehn; Paul J. Marshall; Richard J. Kulmacz


Book ID
114101187
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
72 KB
Volume
59
Category
Article
ISSN
0090-6980

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## Abstract Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's suscep