Hydration energy landscape of the active
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Volkhard Helms; Rebecca C. Wade
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Article
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1998
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John Wiley and Sons
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English
โ 221 KB
Hydration of protein cavities influences protein stability, dynamics, and function. Protein active sites usually contain water molecules that, upon ligand binding, are either displaced into bulk solvent or retained to mediate protein-ligand interactions. The contribution of water molecules to ligand