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Rapid identification of CD4+ T-cell epitopes using yeast displaying pathogen-derived peptide library

✍ Scribed by Fei Wen; Olga Esteban; Huimin Zhao


Book ID
113717547
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
677 KB
Volume
336
Category
Article
ISSN
0022-1759

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We synthesized Xn (n = 9-19) peptides that consist of 9 to 19 residues with random sequences. X19 is considered to deliver antigenic stimuli to CD4 T cells, because: (a) X19 induces proliferation of peripheral blood mononuclear cells (PBMC), in the presence of IL-2, which is abrogated by monoclonal