## Abstract The morphogenesis and movement of bile canaliculi (BC) are not well understood. This is because culture of hepatocytes that maintain polarity of cell membranes and possess highly differentiated functions has never been successful. We found that small hepatocytes (SHs), which are known t
Rapid formation of hepatic organoid in collagen sponge by rat small hepatocytes and hepatic nonparenchymal cells
β Scribed by Keisuke Harada; Toshihiro Mitaka; Shigeki Miyamoto; Shinichi Sugimoto; Shinichiro Ikeda; Hiroshi Takeda; Yohichi Mochizuki; Koichi Hirata
- Book ID
- 117372031
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 567 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0168-8278
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## Abstract Small hepatocytes (SHs) are hepatic progenitor cells with hepatic characteristics. They can proliferate to form colonies in culture and change their morphology from flat to rising/piledβup with bile canaliculi (BC), which results in maturation. In this study, we examined whether SHs cou
We have shown, using the proline:ornithine dual label method, that in normal rats, hepatocytes contribute in vivo about 80 to 90% of the newly synthesized hepatic collagen. In order to quantify the contribution of hepatocytes and nonparenchymal cells to collagen synthesis in vivo in hepatic fibrogen