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Rapid Diagnosis of Gastric Malignant Lymphoma from Biopsy Specimens: Detection of Immunoglobulin Heavy Chain Rearrangement by Polymerase Chain Reaction

✍ Scribed by Ono, Hiroyuki ;Kondo, Hitoshi ;Saito, Daizo ;Yoshida, Shigeaki ;Shirao, Kuniaki ;Yamaguchi, Hajime ;Yokota, Toshihiro ;Hosokawa, Koichi ;Fukuda, Haruhiko ;Hayashi, Shuya ;Ochiai, Atsushi ;Oguro, Yanao

Book ID: 108579689
Publisher: Wiley (Blackwell Publishing)
Year: 1993
Tongue: English
Weight: 298 KB
Volume: 84
Category: Article
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1993.tb02049.x

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## BACKGROUND. The demonstration of the monoclonality of immunoglobulin heavy chain (IgH) gene rearrangement is an indispensable method for the diagnosis of B-cell lymphoma as well as histocytochemical analysis. For the detection of IgH gene rearrangement, the extraction of DNA from a homogenous c