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Rapid detection of the hepatitis B virus YMDD mutant using TaqMan-minor groove binder probes

✍ Scribed by Rui Hua; Yasuo Tanaka; Kenichi Fukai; Motohisa Tada; Motoko Seto; Yoshinari Asaoka; Miki Ohta; Tadashi Goto; Fumihiko Kanai; Naoya Kato; Haruhiko Yoshida; Takao Kawabe; Osamu Yokosuka; Masao Omata


Book ID
116347995
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
146 KB
Volume
395
Category
Article
ISSN
0009-8981

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## Abstract The UGT1A1 Taqman MGB probe single nucleotide polymorphism (SNP) genotyping assay was developed to detect nucleotide 211 of the UDP‐glucoronocyltransferase 1A1 (UGT1A1) gene. Defects in this enzyme interfere with process of conjugation of bilirubin and cause unconjugated hyperbilirubine