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Rapid detection of phenylketonuria mutations by non-radioactive single-strand conformation polymorphism analysis

✍ Scribed by YEQI YAO; YOICHI MATSUBARA; KUNIAKI NARISAWA


Book ID
118711984
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
430 KB
Volume
36
Category
Article
ISSN
1328-8067

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This report describes a rapid convenient screening system with improved sensitivity to detect mutations in the cystic fibrosis transmembrane regulator (CFTR) gene based on nonisotopic SSCP analysis. Because conventional SSCP analysis is often hampered by poor yield of single-stranded DNA, we applied