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Rapid detection of deletional α-thalassemia by an oligonucleotide microarray

✍ Scribed by Li Zesong; Guo Ruijun; Zhang Wen


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
83 KB
Volume
80
Category
Article
ISSN
0361-8609

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Fetuses with homozygous alpha-thalassemia 1, in which the deletion of all four alpha-globin genes results in the absence of any alpha-globin chains, are severely anemic with clinical features of hydrops fetalis. Definitive diagnosis of alpha-thalassemia 1 carriers is difficult since there are few re