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Rapid detection of a mutation hot-spot in the human androgen receptor

✍ Scribed by Helena Malmgren; Jan Gustavsson; Torsten Tuvemo; Niklas Dahl


Book ID
115091833
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
334 KB
Volume
50
Category
Article
ISSN
0009-9163

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## Abstract In a subset of endocrine therapy‐resistant prostate cancers, amino acid substitutions H874Y, T877A and T877S, which broaden ligand specificity of the ligand binding domain (LBD) of the androgen receptor (AR), have been detected. To increase our knowledge of the role of amino acid substi