## Abstract Few studies have examined the duration of protection following vaccination against hepatitis A virus (HAV) with currently licensed HAV vaccines. This study explored the longโterm immunogenicity in individuals vaccinated with the virosomal hepatitis A virus, Epaxalยฎ. Adult volunteers (Nโ
Rapid Antibody Response after Vaccination with a Virosomal Hepatitis A Vaccine
โ Scribed by F. Ambrosch; B. Finkel; C. Herzog; A. Koren; H. Kollaritsch
- Book ID
- 107705290
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 252 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0300-8126
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## Abstract The aim of this study was to predict the longโterm protection induced after immunisation with inactivated, aluminiumโfree virosome hepatitis A vaccine. The study population consisted of adult volunteers enrolled in four different clinical trials. Lower 95% confidence interval limits and
Very few studies with inactivated hepatitis A vaccines were designed for long-term follow-up of antibody persistence. Based on the serological data from these vaccine trials, mathematical models were developed to predict the decrease of anti-hepatitis A virus (anti-HAV) antibodies after vaccination.
A human monoclonal antibody type IgG4, designated 1Ff4, was obtained by Epstein Barr virus transformation of peripheral blood lymphocytes from a hepatitis B vaccinee (HB-VAX: plasmaderived vaccine) after one boost of yeast recombinant DNA derived vaccine (Engerix-B). 1Ff4 binds preferentially to HBs