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Rapid and sensitive screening for CEBPA mutations in acute myeloid leukaemia

✍ Scribed by Tobias Benthaus; Friederike Schneider; Gudrun Mellert; Evelyn Zellmeier; Stephanie Schneider; Purvi M. Kakadia; Wolfgang Hiddemann; Stefan K. Bohlander; Michaela Feuring-Buske; Jan Braess; Karsten Spiekermann; Annika Dufour


Book ID
108675940
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
318 KB
Volume
143
Category
Article
ISSN
0007-1048

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CEBPA encodes the transcription factor C/EBPalpha and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t(8;21). In much the same way as specific transl