✦ LIBER ✦

Rapid and highly selective GC/MS/MS detection of heroin and its metabolites in hair

✍ Scribed by A Polettini; A Groppi; M Montagna

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 536 KB
Volume: 63
Category: Article
ISSN: 0379-0738
DOI: 10.1016/0379-0738(93)90275-f

No coin nor oath required. For personal study only.

✦ Synopsis

A direct treatment of methanol-washed hair with a silylating solution is proposed to extract heroin, O-6-monoacetylmorphine, morphine, acetylcodeine, and codeine, obtaining the simultaneous derivatization of the hydroxylated metabolites and reducing potential sample contamination. Analysis is performed by capillary gas chromatography-tandem mass spectrometry (GC/MS/MS) using multiple selected reaction monitoring. Owing to the selectivity and sensitivity of the GC/MS/MS analysis, and to the extremely simple treatment of the sample, the method fulfils the requirements of both clinical and forensic diagnosis of heroin use.

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