Rapid and efficient solid phase syntheses of cyclic peptides with endocyclic biaryl ether bonds

✍ Scribed by Kevin Burgess; Dongyeol Lim; Michele Bois-Choussy; Jieping Zhu

• Book ID: 104257018
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 226 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00654-0

✦ Synopsis

Solid phase syntheses of the OF4949 derivatives 1 and 6 -9 were performed via protection/deprotection of tyrosine side-chains on a support, and SNAr macrocyclization reactions.