Reactive systemic AA amyloidosis is a severe complication of rheumatoid arthritis (RA), occurring in 2-5% of RA patients (1). Infliximab, a monoclonal antibody against tumor necrosis factor β£ (TNFβ£), is successfully used in the treatment of RA (2). TNFβ£ plays a key role in inducing the synthesis of
Rapid and complete resolution of proteinuria due to renal amyloidosis in a patient with rheumatoid arthritis treated with infliximab
β Scribed by Ori Elkayam; Philip N. Hawkins; Helen Lachmann; Michael Yaron; Dan Caspi
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 31 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0004-3591
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β¦ Synopsis
Abstract
We describe herein a patient with rheumatoid arthritis who developed proteinuria due to AA amyloidosis, in whom the inflammatory disease was rapidly and completely suppressed by treatment with infliximab. This response was accompanied by resolution of the proteinuria and stabilization of the amyloid deposits as seen on serial ^123^Iβlabeled serum amyloid P scintigraphy.
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