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Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK

✍ Scribed by Thomas, Gareth M; Lin, Da-Ting; Nuriya, Mutsuo; Huganir, Richard L


Book ID
110032339
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
573 KB
Volume
27
Category
Article
ISSN
0261-4189

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The present investigation provides the first indication that constitutive, calcium-independent phospholipase A 2 activity (iPLA 2 ) modulates phosphorylation of the ␣-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtype of glutamate receptors. Preincubation of frozenthawed brain sections wi