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Rapid analytical gel filtration chromatography: III. Apparent Molecular Weight Distribution of Peptides Produced by Proteolysis

✍ Scribed by Nicholas Catsimpoolas


Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
638 KB
Volume
61
Category
Article
ISSN
0003-2697

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✦ Synopsis


A rapid gel filtration chromatography method is described for determination of the molecular weight distribution (MWD) of peptide mixtures by using calibrated Sephadex microbore columns. The method was applied to MWD analysis of peptide mixtures resulting from trypsin and pepsin digestion of glycinin-the major soybean storage protein-under different incubation conditions of pH, temperature, and time of hydrolysis. Possible sources of errors and suggestions for improvement are discussed.