✦ LIBER ✦

Rapid analysis of amphetamines in blood using head space-solid phase microextraction and selected ion monitoring

✍ Scribed by Nobuyuki Nagasawa; Mikio Yashiki; Yasumasa Iwasaki; Kenji Hara; Tohru Kojima

Book ID: 103902683
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 399 KB
Volume: 78
Category: Article
ISSN: 0379-0738
DOI: 10.1016/0379-0738(95)01874-3

No coin nor oath required. For personal study only.

✦ Synopsis

A simple and rapid method for analysis of methamphetamine (MA) and amphetamine (AP) in blood was developed using head space-solid phase microextraction (HS-SPME) and gas chromatography-mass spectrometry/electron impact ionization-selected ion monitoring (GC-MS/EI-SIM). A vial containing a blood sample, sodium hydroxide, and pentadeuterated methamphetamine as an internal standard, was heated at 80 degrees C for 20 min. The extraction fiber of the SPME was exposed for 5 min in the head space of the vial. First, heptafluorobutyric anhydride solution was injected into the injection port of the GC-MS to make heptafluorobutyramide (HFB) derivatives of amphetamines, and compounds absorbed on the fiber were detached by exposing the fiber in the injection port. Straight calibration curves of MA and AP were obtained from 0.01 to 2 micrograms/g in blood, respectively. No interfering substances were found, and the time for analysis was 30 min for one sample.

📜 SIMILAR VOLUMES

Detection of amphetamines in urine using

Detection of amphetamines in urine using head space-solid phase microextraction and chemical ionization selected ion monitoring

✍ Mikio Yashiki; Tohru Kojima; Tetsuji Miyazaki; Nobuyuki Nagasawa; Yasumasa Iwasa 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 676 KB

Analysis of amphetamine, methamphetamine

Analysis of amphetamine, methamphetamine, methylenedioxyamphetamine and methylenedioxymethamphetamine in whole blood using in-matrix ethyl chloroformate derivatization and automated headspace solid-phase microextraction followed by GC-MS

✍ Jeff Wise; Terry Danielson; Ashraf Mozayani; Richard Li 📂 Article 📅 2008 🏛 Springer Japan 🌐 English ⚖ 189 KB

Headspace-solid phase microextraction of

Headspace-solid phase microextraction of selenium(IV) from human blood and water samples using polypyrrole film and analysis with ion mobility spectrometry

✍ Parvin Shahdousti; Naader Alizadeh 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 374 KB

Monitoring of the principal carbonyl com

Monitoring of the principal carbonyl compounds involved in malolactic fermentation of wine by solid-phase microextraction and positive ion chemical ionization GC/MS analysis

✍ Riccardo Flamini; Antonio Dalla Vedova; Annarita Panighel; Nicola Perchiazzi; St 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB

## Abstract A new method has been developed to determine acetaldehyde, 2,3‐butanedione (diacetyl) and 3‐hydroxy‐2‐butanone (acetoin) in wine by solid‐phase microextraction (SPME) and positive ion chemical ionization GC/MS analysis of __O__‐(2,3,4,5,6‐pentafluorobenzyl)‐hydroxylamine (PFBOA) derivat

Rapid analysis of captopril in human pla

Rapid analysis of captopril in human plasma and pharmaceutical preparations by headspace solid phase microextraction based on polypyrrole film coupled to ion mobility spectrometry

✍ Akarm Karimi; Naader Alizadeh 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 678 KB

Optimization of headspace sampling using

Optimization of headspace sampling using solid-phase microextraction for chloroanisoles in cork stoppers and gas chromatography–ion-trap tandem mass spectrometric analysis

✍ Federica Bianchi; Maria Careri; Alessandro Mangia; Marilena Musci 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 743 KB

## Abstract In a study aiming to characterize cork off‐flavour for quality control purposes, chloroanisoles were extracted and identified from cork stoppers by means of solid‐phase microextraction (SPME)–gas chromatography–ion‐trap mass spectrometry (GC–ITMS). An experimental design procedure was u