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Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

✍ Scribed by David A. Hume; Mary R. Thornton; Maurice J. Weidemann; Volker Speth

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 618 KB
Volume: 101
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041010318

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✦ Synopsis

Abstract

Under conditions where a maximum stimulation of 3‐O‐methyl‐glucose transport is observed, three thymocyte mitogens (concanavalin A, ionophore A23187 and hydrogen peroxide) cause cell rounding and a decrease in the density of intra‐membrane particles on the plasma membrane. The early effects of mitogens on the thymocyte plasma membrane are similar to those of osmotic shock.

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