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Rapid Aggregate Formation of the Huntingtin N-Terminal Fragment Carrying an Expanded Polyglutamine Tract

✍ Scribed by Noriko Hazeki; Koichiro Nakamura; Jun Goto; Ichiro Kanazawa


Book ID
115583447
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
163 KB
Volume
256
Category
Article
ISSN
0006-291X

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Cells exposed to a huntingtin fragment c
✍ Anne Nørremølle; Morten Grunnet; Lis Hasholt; Sven Asger Sørensen 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

## Abstract Ion channels formed by expanded polyglutamine tracts have been proposed to play an important role in the pathological processes leading to neurodegeneration in Huntington's disease and other CAG repeat diseases. We tested the capacity of a huntingtin fragment containing an expanded poly