Rapid activation of ornithine decarboxylase by mitogenic (but not by nonmitogenic) ligands in human T lymphocytes

✍ Scribed by Ian G. Scott; Hannu Poso; Karl E. O. Akerman; Leif C. Andersson

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 528 KB
• Volume: 15
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830150808

✦ Synopsis

Rapid activation of ornithine decarboxylase by mitogenic (but not by nonmitogenic) ligands in human T lymphocytes*

The T cell mitogens, concanavalin A and the monoclonal antibody OKT3, cause a rapid activation of ornithine decarboxylase (ODC) activity in human T lymphocytes, maximal within 10 min of mitogen addition. Nonmitogenic ligands to T cell surface structures do not induce ODC. The enzyme induction is dependent upon an intact mobility of ligand-receptor complex, requires a functioning energy metabolism, but is independent of de nuvo protein synthesis. The early induction of pre-existing ODC molecules appears to be specifically linked to the initiation of T lymphocyte proliferation.