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Rapamycin inhibits the constitutively active Frap-p70S6K pathway and autonomous cell growth in human pancreatic cancer cells

✍ Scribed by Martin Grewe; Frank Gansauge; Guido Adler; Thomas Seufferlein


Book ID
119424222
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
177 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract Ascochlorin, a non‐toxic prenylphenol compound derived from the fungus __Ascochyta viciae__, has been shown recently to have anti‐cancer effects on various human cancer cells. However, the precise molecular mechanism of this anti‐cancer activity remains to be elucidated. Here, we invest