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RANKL induces components of the extrinsic coagulation pathway in osteoclasts

✍ Scribed by Erik Karlström; Barbro Ek-Rylander; Mikael Wendel; Göran Andersson

Book ID: 116300025
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 703 KB
Volume: 394
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.03.025

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## Abstract During bone resorption, osteoclasts are exposed to high Ca^2+^ concentrations (up to 40 mM). The role of high extracellular Ca^2+^ in receptor activator of NF‐κB ligand (RANKL)‐mediated osteoclast survival and their functional interrelationship is unclear. In this study, we show that RA