𝔖 Bobbio Scriptorium
✦   LIBER   ✦

RANKL-dependent and RANKL-independent mechanisms of macrophage-osteoclast differentiation in breast cancer

✍ Scribed by Y. S. Lau; L. Danks; S. G. Sun; S. Fox; A. Sabokbar; A. Harris; N. A. Athanasou

Publisher
Springer US
Year
2006
Tongue
English
Weight
373 KB
Volume
105
Category
Article
ISSN
0167-6806

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Thyroid hormone stimulates osteoclast di
Thyroid hormone stimulates osteoclast differentiation by a mechanism independent of RANKL–RANK interaction
✍ Masanori Kanatani; Toshitsugu Sugimoto; Hideaki Sowa; Tatsuya Kobayashi; Michiko 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 198 KB

## Abstract It is well known that thyroid hormone excess causes bone loss. However, the precise mechanism of bone loss by thyroid hormone still remains unclear. When T~3~ was added to unfractionated bone cells after degeneration of pre‐existent osteoclasts, T~3~ (1 pM–100 nM) dose‐dependently stimu

TRAIL inhibits osteoclastic differentiat
TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors
✍ Giorgio Zauli; Erika Rimondi; Susanna Stea; Fabio Baruffaldi; Marco Stebel; Carl 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 388 KB

## Abstract Experimental evidences indicate that the TNF family member TNF‐related apoptosis inducing ligand (TRAIL) might be involved in modulating osteoclastic differentiation. The ability of recombinant soluble TRAIL to affect bone density in vivo was evaluated by using 4‐week‐old mice subcutane

Roles of stromal cell RANKL, OPG, and M-
Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-β regulation of osteoclast differentiation
✍ Mary Karst; Genevieve Gorny; Rachelle J. Sells Galvin; Merry Jo Oursler 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB

## Abstract To better understand the complex roles of transforming growth factor‐beta (TGF‐β) in bone metabolism, we examined the impact of a range of TGF‐β concentrations on osteoclast differentiation. In co‐cultures of support cells and spleen or marrow osteoclast precursors, low TGF‐β concentrat

A novel T cell cytokine, secreted osteoc
A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner
✍ Leonard Rifas; M. Neale Weitzmann 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 544 KB

## Abstract ## Objective Chronic T cell activation is central to the etiology of rheumatoid arthritis (RA), an inflammatory autoimmune disease that leads to severe focal bone erosions and generalized systemic osteoporosis. Previous studies have shown novel cytokine‐like activities in medium contai

Induction of chemokines and chemokine re
Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES
✍ Michael S. Kim; Carly L. Magno; Christopher J. Day; Nigel A. Morrison 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB

## Abstract Chemokines MCP‐1 and RANTES are induced when authentic bone resorbing human osteoclasts differentiate from monocyte precursors in vitro. In addition, MCP‐1 and RANTES can stimulate the differentiation of cells with the visual appearance of osteoclasts, being multinuclear and positive fo

Calcium/calmodulin-dependent kinase acti
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL)
✍ Estabelle S.M. Ang; Ping Zhang; James H. Steer; Jamie W.-Y. Tan; Kirk Yip; Ming 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 521 KB

## Abstract Calcium/calmodulin‐dependent protein kinase (CaMK) is a major down stream mediator of Ca^2+^ signaling in a wide range of cellular functions, including ion channel and cell cycle regulation and neurotransmitter synthesis and release. Here we have investigated the role of the CaMK signal