## Abstract TNFฮฑ is a major osteoclastogenic cytokine and a primary mediator of inflammatory osteoclastogenesis. We have previously shown that this cytokine directly targets osteoclasts and their precursors and that deletion of its typeโ1 receptor (TNFr1) lessens osteoclastogenesis and impacts RANK
RANK ligand, RANK, and OPG expression in type
โ Scribed by Hiroyuki Mori; Riko Kitazawa; Shinichi Mizuki; Masato Nose; Sakan Maeda; Sohei Kitazawa
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 958 KB
- Volume
- 117
- Category
- Article
- ISSN
- 1432-119X
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## Abstract Tumor necrosis factor (TNF)โฮฑ is known for its osteoclastogenic and resorptive activities. Induction of osteoclastogenesis by receptor activator of NFโฮบB ligand (RANKL) is accompanied by increased TNFโฮฑ expression. In the present study we investigated the mechanism by which RANKL induce
## Abstract Receptor activator of NFโฮบB ligand (RANKL) is a critical osteoclastogenic factor that is expressed on bone marrow stromal/preosteoblast cells. Most bone resorption stimuli induce osteoclast formation by modulating RANKL expression in these cells. However, little is known about the mecha