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Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo

โœ Scribed by John Lowe; James Araujo; Jihong Yang; Mike Reich; Amy Oldendorp; Vanessa Shiu; Valerie Quarmby; Henry Lowman; Samantha Lien; Jacques Gaudreault; Mauricio Maia

Book ID
116456630
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
185 KB
Volume
85
Category
Article
ISSN
0014-4835

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Vascular endothelial growth factor (VEGF) is a potent angiogenic stimulator that acts by binding to high-affinity transmembrane receptors. Although both VEGF and its receptors are overexpressed in human pancreatic ductal adenocarcinoma (PDAC), this malignancy is not generally considered to be highly