Randomized trial to evaluate the addition of tamoxifen to cyclophosphamide, 5-fluorouracil, prednisone adjuvant therapy in premenopausal women with node-positive breast cancer
β Scribed by James N. Ingle; Lloyd K. Everson; H. Sam Wieand; Stephen A. Cullinan; Lester E. Wold; Jeffrey B. Hagen; J. Kirk Martin; James E. Krook; Robert G. Fitzgibbons; John F. Foley; David L. Ahmann; Delano M. Pfeifle; Stephanie J. Green
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 787 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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A prospective randomized study was conducted to compare the adjuvant efficacy of six cycles of high-dose ACMF (Adriamycin, ADM; cyclophosphamide, CPA; methotrexate, MTX; 5-fluorouracil, 5-FU) with that of 12 cycles of low-dose ACMF in premenopausal, node-positive breast cancer patients. The six-cycl
## Abstract ## BACKGROUND The PreβOperative βArimidexβ Compared to Tamoxifen (PROACT) study was a randomized, multicenter study comparing anastrozole with tamoxifen as a preoperative treatment of postmenopausal women with large, operable (T2/3, N0β2, M0), or potentially operable (T4b, N0β2, M0) br