✦ LIBER ✦

Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes

✍ Scribed by Michael D. Kelly; Julie King; Maya Cherian; Simon J. Dwerryhouse; Ian G. Finlay; Warwick J. Adams; Denis W. King; David Z. Lubowski; David L. Morris

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 80 KB
Volume: 85
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990415)85:8<1658::aid-cncr3>3.0.co;2-q

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Previous studies have suggested that cimetidine, a histamine-2 receptor antagonist with immunostimulatory effects, may improve survival in patients with colorectal carcinoma. This effect may be apparent by an increase in the number of peritumoral lymphocytes. A prospective, double blind, randomized, placebo-controlled trial of a short course of preoperative treatment with cimetidine in patients with colorectal carcinoma was performed to assess the effect of cimetidine on survival and on the number of peritumoral lymphocytes.

METHODS.

One hundred and twenty-five patients who were scheduled to undergo elective colon or rectal excision for carcinoma were randomized to receive either placebo or cimetidine preoperatively for 5 days. In addition to standard histopathology, immunohistochemistry and computer video image analysis were used to assess the number of peritumoral lymphocytes in an objective manner. Interim survival analysis according to the Kaplan-Meier method was performed.

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