Randomized trial of IPX066, carbidopa/levodopa extended release, in early Parkinson's disease
✍ Scribed by Pahwa, Rajesh; Lyons, Kelly E.; Hauser, Robert A.; Fahn, Stanley; Jankovic, Joseph; Pourcher, Emmanuelle; Hsu, Ann; O'Connell, Martin; Kell, Sherron; Gupta, Suneel
- Book ID
- 122334822
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 897 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1353-8020
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## Abstract We performed a 39‐week, randomized, double‐blind, multicenter study to compare the efficacy, safety, and tolerability of levodopa/carbidopa/entacapone (LCE, Stalevo) with levodopa/carbidopa (LC, Sinemet IR) in patients with early Parkinson's disease (PD). Four hundred twenty‐three patie
## Abstract The objective of the study was to compare the pharmacokinetics, motor effects, and safety of IPX066, a novel extended‐release formulation of carbidopa‐levodopa, with an immediate‐release carbidopa‐levodopa formulation in advanced Parkinson's disease. We performed an open‐label crossover