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Randomized phase III trial of radiation treatment ± amifostine in patients with advanced-stage lung cancer

✍ Scribed by Dosia Antonadou; Nikos Coliarakis; Maria Synodinou; Helen Athanassiou; Athina Kouveli; Cosmas Verigos; Grigoris Georgakopoulos; Katerina Panoussaki; Pantelis Karageorgis; Nicolas Throuvalas


Book ID
108434397
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
136 KB
Volume
51
Category
Article
ISSN
0360-3016

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## Abstract ## BACKGROUND. Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dos