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Randomized, phase II dose-finding studies of a modified tick-borne encephalitis vaccine: evaluation of safety and immunogenicity

✍ Scribed by Hartmut J. Ehrlich; Borislava G. Pavlova; Sandor Fritsch; Eva-Maria Poellabauer; Alexandra Loew-Baselli; Ortrun Obermann-Slupetzky; Friedrich Maritsch; Ingeborg Cil; Friedrich Dorner; P.Noel Barrett

Book ID: 117431847
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 165 KB
Volume: 22
Category: Article
ISSN: 0264-410X
DOI: 10.1016/s0264-410x(03)00563-2

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## Abstract The chimeric flavivirus LGT/DEN4 containing prM and E genes of naturally attenuated Langat virus with remaining sequence derived from low neuroinvasive Dengue 4 virus was previously produced and assessed as a candidate for live vaccine against tick‐borne encephalitis (TBE) [Pletnev and