Randomized, double-blind, placebo-controlled trial of corticosteroids after Kasai portoenterostomy for biliary atresia

✍ Scribed by Mark Davenport; Mark D. Stringer; Sarah A. Tizzard; Patricia McClean; Giorgina Mieli-Vergani; Nedim Hadzic

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 190 KB
• Volume: 46
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.21873

✦ Synopsis

The objective of this study was to evaluate adjuvant corticosteroids after Kasai portoenterostomy for biliary atresia. The study consisted of a prospective, 2-center, double-blind, randomized, placebo-controlled trial of post-Kasai portoenterostomy corticosteroids (oral prednisolone: 2 mg/kg/day from day 7 to day 21 and 1 mg/kg/day from day 22 to day 28). The data were compared with 2 or Mann-Whitney tests, as appropriate. Seventy-one postoperative infants with type 3 biliary atresia were randomized to receive either oral prednisolone (n ‫؍‬ 36) or a placebo (n ‫؍‬ 37). At 1 month, the median bilirubin level was lower in the steroid group (66 versus 92 mol/L, P ‫؍‬ 0.06), but no difference was evident at 6 (P ‫؍‬ 0.56) or 12 (P ‫؍‬ 0.3) months. The proportion of infants with a normal bilirubin level (<20 mol/L) at 6 (47% versus 49%, P ‫؍‬ 0.89) and 12 months (50% versus 40%, P ‫؍‬ 0.35) was not significantly different. The need for transplantation by 6 (12% versus 13%, P ‫؍‬ 0.99) and 12 months (26% versus 35%, P ‫؍‬ 0.47) was not significantly different. The steroid effect was more pronounced in younger infants (less than 70 days at Kasai portoenterostomy, n ‫؍‬ 51), with a reduced bilirubin level at 1 month (64 versus 117 mol/L, P ‫؍‬ 0.01) and with a greater proportion with a normal bilirubin level at 12 months (54% versus 37%, P ‫؍‬ 0.22).

Conclusion:

There was a beneficial effect on the rate of reduction of bilirubin in the early postoperative period (specifically in infants less than 70 days old at surgery), but this steroid regimen did not reduce the need for liver transplantation.