Randomized, controlled trial of carvedilol versus nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding
β Scribed by Lo, Gin-Ho; Chen, Wen-Chi; Wang, Huay-Min; Yu, Hsien-Chung
- Book ID
- 118704551
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 291 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0815-9319
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Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history were considered for
Current therapy for preventing the first variceal bleed includes beta-blocker and variceal band ligation (VBL). VBL has lower bleeding rates, with no differences in survival, whereas beta-blocker therapy can be limited by side effects. Carvedilol, a non-cardioselective vasodilating beta-blocker, is