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Randomized controlled trial of adenine arabinoside 5′-monophosphate in chronic active hepatitis B: Comparison of the efficacy in heterosexual and homosexual patients

✍ Scribed by Patrick Marcellin; Denis Ouzan; Françoise Degos; Christian Brechot; Etienne-Henri Metman; Claude Degott; Michelle Chevalier; Pierre Berthelot; Christian Trepo; Jean-Pierre Benhamou

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 459 KB
Volume: 10
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840100313

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty-two heterosexuals and 2 1 homosexuals with chronic active hepatitis B and who had HBsAg, HBeAg and hepatitis B virus DNA in serum were randomized separately to receive adenine arabinoside monophosphate or placebo. In the 10 heterosexuals and nine homosexuals who received placebo, no change in hepatitis B virus DNA level and HBeAg was observed. Among the patients who received adenine arabinoside monophosphate, seven of the 12 heterosexuals and five of the 12 homosexuals lost hepatitis B virus DNA; five heterosexuals and three homosexuals also lost HBeAg; one

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