Randomized clinical trial of topiramate for levodopa-induced dyskinesia in Parkinson's disease
✍ Scribed by Kobylecki, Christopher; Burn, David J.; Kass-Iliyya, Lewis; Kellett, Mark W.; Crossman, Alan R.; Silverdale, Monty A.
- Book ID
- 121495630
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 200 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Levodopa‐induced ocular dyskinesias are very uncommon. Usually they occur simultaneously with limb peak‐dose choreatic dyskinesias. We report on a patient with leftward and upward deviations of gaze during the peak effect of levodopa, and hypothesize that a severe dopaminergic denervati
## Abstract Overactive AMPA receptor‐mediated transmission may be involved in the pathogenesis of levodopa‐induced dyskinesia. The mechanism of action of the anticonvulsant drug topiramate involves attenuation of AMPA receptor‐mediated transmission. In this study, the potential antidyskinetic actio