Randomized clinical trial of single- versus multiple-dose antimicrobial prophylaxis in gastric cancer surgery

✍ Scribed by Y. Mohri; H. Tonouchi; M. Kobayashi; K. Nakai; M Kusunoki

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 110 KB
• Volume: 94
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.5837

✦ Synopsis

Abstract

Background

The optimum duration of antimicrobial prophylaxis in elective gastric cancer surgery is still open to question. This multicentre randomized clinical trial compared a single-dose with a multiple-dose regimen of antimicrobial prophylaxis for prevention of surgical-site infection.

Methods

Between May 2001 and December 2004, 501 patients undergoing elective surgery for gastric cancer in ten centres were allocated randomly to single- or multiple-dose antimicrobial prophylaxis. The primary outcome measure was the incidence of surgical-site infection, analysed by intention to treat.

Results

Some 243 patients who received a single dose and 243 who received multiple doses of antibiotics were included in the final analysis. The surgical-site infection rate was 9·5 per cent (23 of 243) and 8·6 per cent (21 of 243) respectively (difference 0·9 (95 per cent confidence interval − 4·3 to 5·9) per cent). Antimicrobial prophylaxis had no major adverse effects.

Conclusion

The incidence of surgical-site infection in elective gastric cancer surgery was similar with both antibiotic prophylaxis regimens.