Abstract
Background
It is questionable whether elective appendicectomy can effectively reduce persistent or recurrent right lower-quadrant abdominal pain due to chronic or recurrent appendicitis.
Methods
This single-centre double-blind randomized clinical trial studied the effects of elective laparoscopic appendicectomy on pain 6 months after operation in patients with persistent or recurrent lower-quadrant pain. A secondary outcome evaluated was the relationship between clinical response and appendiceal histopathology. The analysis was performed on an intention-to-treat basis.
Results
Forty patients were randomized to laparoscopic appendicectomy (18) or laparoscopic inspection only (22). Postoperative pain scores differed significantly between the groups, favouring appendicectomy (P = 0ยท005). Relative risk calculations indicated that there was a 2ยท4 (95 per cent confidence interval (c.i.) 1ยท3 to 4ยท0) times greater chance of improvement in pain after laparoscopic appendicectomy. The number needed to treat was 2ยท2 (95 per cent c.i. 1ยท5 to 6ยท5). There was no association between postoperative pain scores and histopathology findings.
Conclusion
Persistent or recurrent lower abdominal pain can be treated by elective appendicectomy with significant pain reduction in properly selected cases. Histopathology may not be abnormal. Registration number: ISRCTN48831122 (http://www.controlled-trials.com).